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RNA-seq analysis after 24hr of ACBI-1 treatment on DND-41 and MOLT-4 cells.

ABSTRACT: RNA-seq analysis was performed in two T-ALL cell lines (DND-41 and MOLT-4) to analyze gene expression changes after 24 hours of 100nM ACBI-1 or DMSO treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230590 | GEO | 2024/07/02

REPOSITORIES: GEO

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RNA-seq analysis after 8hr of ACBI-1 treatment on DND-41 and MOLT-4 cells.

Project description:RNA-seq analysis was performed in two T-ALL cell lines (DND-41 and MOLT-4) to analyze gene expression changes after 8 hours of 100nM ACBI-1 or DMSO treatment.

2024-07-02 | GSE230589 | GEO

RNA-seq analysis after 3hr of ACBI-1 treatment on DND-41 and MOLT-4 cells.

Project description:RNA-seq analysis was performed in two T-ALL cell lines (DND-41 and MOLT-4) to analyze gene expression changes after 3 hours of 100nM ACBI-1 or DMSO treatment.

2024-07-02 | GSE230588 | GEO

H3K27ac Hi-ChIP analysis in MOLT-4 and DND-41 cells.

Project description:H3K27ac Hi-ChIP analysis was performed in MOLT-4 and DND-41 cells to analyze active chromatin-chromatin interactions after DMSO or ACBI-1 treatment.

2024-07-02 | GSE230591 | GEO

ATAC-seq analysis for DND-41 and MOLT4 cells with ACBI-1 treatment

Project description:ATAC-seq analysis was performed in two T-ALL cell lines (DND-41 and MOLT-4) with either DMSO or ACBI-1 treatment at two different time points (3hr and 24hr).

2024-07-02 | GSE230584 | GEO

Cut&Run analysis for transcription factors in DND-41 cells

Project description:Cut&Run analysis was performed in DND-41 cells to analyze the basal level of H3K27ac and DNA bindings of BRG1 and RUNX1 after DMSO or ACBI-1 treatment.

2024-07-02 | GSE230593 | GEO

ATAC-seq from DND-41 (ENCSR660WSB)

Project description:ATAC-seq on human cell line DND-41 For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-04-22 | GSE172903 | GEO

CRISPR/Cas9 screen of T-ALL cells (DND-41) in the presence of DMSO, CB-103 or GSI (DAPT).

Project description:The efficacy of targeted therapies for treatment of cancer patients is often limited by development of drug resistance. Potential resistance mechanisms to pharmacological Notch1 inhibition mediated by GSI or CB-103 in T-ALL are currently unclear. Thus, we performed a genome-wide loss-of-function (LoF) CRISPR/Cas9 screen to identify genes responsible for resistance to Notch inhibition and novel combination therapies for efficient treatment of human T-ALL. We used a Notch-dependent human T-ALL cell line, DND-41, which responds moderately to both GSI and CB-103 treatment in vitro. DND-41 cells stably expressing Cas9 were infected with human GeCKO v2 CRIPSR libraries, containing 123,411 sgRNAs targeting 19,050 genes and treated with either vehicle, GSI or CB-103 for 21 days enabling both positive and negative selection of sgRNAs.

2023-06-26 | GSE221576 | GEO

mRNA-seq of DND-41 T-cell acute lymphoblastic leukemia cell line upon inhibition of hsa-miR-363-3p

Project description:The aim of this study was to investigate the effect of hsa-miR-363-3p on global gene expression in T-cell acute lymphoblastic leukemia (T-ALL). For this purpose we selected DND-41 T-ALL cell line characterized by high expression of this miRNA. The cells were transduced either with miRZip pGreenPuro scrambled vector (System Biosciences) or miRZip anti-hsa-miR-363-3p vector, each variant in three biological replicates. All 6 libraries were sequenced on Illumina NovaSeq6000 platform, in 2x150 mode, with a coverage of 60M paired reads/sample.

2022-04-30 | E-MTAB-11366 | biostudies-arrayexpress

Cut&Run analysis for transcription factors in MOLT-4 cells

Project description:Cut&Run analysis was performed in MOLT-4 cells to analyze the level of H3K27ac and DNA bindings of SMARCA4 and RUNX1 after DMSO or BRM014 treatment.

2024-07-02 | GSE249318 | GEO

Expression profiling MOLT-4 treated with MABL

Project description:Analysis of MOLT-4 cells at various time points up to 6 hours following treatment with mouse anti-CD47 antibody (MABL) and goat anti-mouse IgG (GAM) as the crosslinker of MABL. MABL induces apoptosis in CD47-positive MOLT-4 cells. Cell death signals via CD47 ligation were analyzed by using Affymetrix Human Genome U133A microarray.

2011-04-01 | GSE16494 | GEO

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