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Capture of TAD reorganization endows variant patterns of gene transcription

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230798 | GEO | 2024/04/29

REPOSITORIES: GEO

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Capture of TAD reorganization endows variant patterns of gene transcription (Hi-C)

Project description:TAD (Topologically Associating Domain) reorganization occurs commonly in cell nucleus and contributes to gene activation and inhibition through separation or fusion of adjacent TADs. However, identification of functional genes impacted by TAD alteration and revealing of TAD-reorganization mechanism underlying gene transcription remain to be fully elucidated. Here, we firstly developed a novel approach termed Inter3D to specifically dig out genes regulated by TAD reorganization. By constructing the comprehensive TAD reorganization medicating epigenomic landscapes in tumor cells, we showed that TAD separation interrupted the intrachromosomal loop at MYL12B locus and abrogated its transcription, while TAD fusion generated the chromosomal interaction and triggered CYP27B1 activation. Our study provides a comprehensive insight into capture of TAD rearrangement-mediated gene loci and moves towards recognizing the functional role of TAD reorganization in gene transcription.

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Capture of TAD reorganization endows variant patterns of gene transcription (RNA-Seq)

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Capture of TAD reorganization endows variant patterns of gene transcription

Project description:Capture of TAD reorganization endows variant patterns of gene transcription

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Capture of TAD reorganization endows variant patterns of gene transcription (ATAC-Seq)

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Capture of TAD reorganization endows variant patterns of gene transcription (Hi-C)

Project description:Capture of TAD reorganization endows variant patterns of gene transcription (Hi-C)

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Capture of TAD reorganization endows variant patterns of gene transcription (RNA-Seq)

Project description:Capture of TAD reorganization endows variant patterns of gene transcription (RNA-Seq)

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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