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Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE230834 | GEO | 2024/07/01

REPOSITORIES: GEO

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Impaired Repopulating Ability of Uhrf2−/− Hematopoietic Progenitor Cells in Mice

Project description:UHRF proteins catalyze the ubiquitination of target proteins and are involved in regulating gene expression. Some studies reported a reduced expression of UHRF2 in acute leukemia cells, but the role of UHRF2 in hematopoiesis remains unknown. Here, we generated Uhrf2−/− mice to clarify the role of UHRF2 deletion in hematopoiesis. Compared to Uhrf2+/+ mice, Uhrf2−/− mice showed no differences in complete blood counts, as well as bone marrow (BM) findings and spleen weights. Proportions of cells in progenitor fractions in BM were comparable between Uhrf2+/+ mice and Uhrf2−/− mice. However, in competitive repopulation assays with BM transplants (BMT), the proportions of Uhrf2−/− cells were decreased relative to Uhrf2+/+ cells in all lineages. After the second BMT, Uhrf2−/− neutrophils were few, while 20–30% of Uhrf2−/− T cells and B cells were still detected. RNA sequencing showed downregulation of some genes associated with stem-cell function in Uhrf2−/− hematopoietic stem/progenitor cells (HSPCs). Interestingly, trimethylated histone H3 lysine 9 was increased in Uhrf2−/− HSPCs in a cleavage under targets and tagmentation assay. While UHRF2 deletion did not cause hematologic malignancy or confer a growth advantage of HSPCs, our results suggest that UHRF2 may play a role in the regulation of hematopoiesis.

| S-EPMC10454722 | biostudies-literature

Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [CUT & Tag]

Project description:We generated Uhrf2-/- mice to clarify the role of deletion of UHRF2 in hematopoiesis. In competitive repopulation assay, the proportions of Uhrf2-/- cells were decreased relative to Uhrf2+/+ cells in all lineages.

2024-07-01 | GSE230833 | GEO

Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [RNA-Seq]

2024-07-01 | GSE230415 | GEO

Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice.

Project description:Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice.

| PRJNA962800 | ENA

Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [CUT & Tag]

Project description:Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [CUT & Tag]

| PRJNA962802 | ENA

Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [RNA-Seq]

Project description:Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. [RNA-Seq]

| PRJNA961104 | ENA

Epigenetic modifier Smchd1 maintains a normal pool of long-term repopulating hematopoietic stem cells in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-20 | GSE188686 | GEO

miR expression profiling of mouse hematopoietic stem and progenitor populations

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-07-24 | E-GEOD-49170 | biostudies-arrayexpress

MYB/miR4863p/MAF/ axis in hematopoietic progenitor cell fate decision

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-07 | E-GEOD-60301 | biostudies-arrayexpress

Hematopoietic progenitor cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE141560 | GEO

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