Transcriptomics

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ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection


ABSTRACT: We generated RNA-seq libraries from three biological replicas of adbp-1 mutant worms at the embryo and L4 developmental stages. We wanted to identify editing sites globally in adbp-1 mutant worms and understand the preferable ADR-2 5’ and 3’ nearest neighbors of editing sites in wild-type worms in contrast to adbp-1 mutant worms. In addition, we wanted to test if the cytoplasmic localization of ADR-2 causes the downregulation of 3’UTR edited genes and lncRNAs, and test the effect of lacking ADBP-1 on global gene expression.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE230883 | GEO | 2024/07/03

REPOSITORIES: GEO

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