Transcriptomics

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Comparative Effects of Statins on Murine Cardiac Gene Expression Profiles in Normal Mice


ABSTRACT: Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs administered. Therefore, the present study was undertaken to compare murine cardiac gene expression following treatment with four different statins. Statins directly regulated cardiac gene expression in a drug-specific manner in mice. The influence of each statin on the cardiac mRNA expression of various genes, including several genes that might be involved in the development of cardiac disease, was not a general effect of this class of drugs.

ORGANISM(S): Mus musculus

PROVIDER: GSE23101 | GEO | 2013/03/31

SECONDARY ACCESSION(S): PRJNA131857

REPOSITORIES: GEO

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