Transcriptomics

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Longitudinal prospective and multicentric peripheral blood immune cell profiling of corneal transplant with acute rejection


ABSTRACT: This study evaluates the peripheral blood mononuclear cell transcriptomes of cornea transplant (CT) recipients from a prospective multi-center clinical study. 244 CT patients were recruited in 5 European clinical centers and biological samples were collected before and 6- and 12-months after the CT. Two groups of patients were recruited: 102 CT patients with a high risk of rejection and 142 with a low risk of rejection. The risk of rejection was defined according to consensus clinical features associated with higher or lower risk of rejection. The gene expression profiles from a total of 572 samples (277 high-risk and 296 low-risk) were generated using Affymetrix transcriptome-wide gene-level expression profiling microarray.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232177 | GEO | 2024/12/20

REPOSITORIES: GEO

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