Transcriptomics

Dataset Information

0

Natural product Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation


ABSTRACT: Purpose: We aimed to find a potential for psoriasis and to explore the mechanism of SBM to relieve psoriasis-like skin inflammation in mice. Methods: Supplementation with smear administration of SBM in the imiquimod-induced murine model, record the weight change and psoriasis Area and Severity Index (PASI) score during the whole process. Using hematoxylin-eosin staining to obverse to skin structure. Performing single-cell RNA sequencing to explore the mechanism of SBM in influencing psoriasis-like phenotype. Immunofluorescence were conducted for verification. Results: SBM remarkably alleviated the psoriasis-like phenotype. Single-cell RNA sequencing analysis shown the expression of Il17 and Il23 was diminished in keratinocytes and T cells, accompanied by a reduction in the proportion of Th17 cells. Meanwhile, endothelial cell activation was inhibited along with the expression of Cxcl16. Conclusion: In this work, we found that natural product SBM inhibited the IL-23/Th17 axis and CXCL16-mediated endothelial activation and had a good therapeutic effect on psoriasis in mice model. This work suggests the potential therapeutic value of SBM in psoriatic patients.

ORGANISM(S): Mus musculus

PROVIDER: GSE232568 | GEO | 2023/11/21

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-02-14 | GSE196677 | GEO
2022-07-20 | GSE208584 | GEO
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
2015-11-25 | E-GEOD-75343 | biostudies-arrayexpress
2023-02-06 | PXD029030 | Pride
2021-10-01 | GSE175470 | GEO
2011-11-30 | E-GEOD-32407 | biostudies-arrayexpress
2021-07-29 | GSE180647 | GEO
2015-11-25 | GSE75343 | GEO
2018-03-12 | GSE110097 | GEO