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Evaluating Differential Tropism, Pathogenesis, and Antiviral Agents of Hemorrhagic Fever Renal Syndrome and Cardiopulmonary Syndrome Causative Hantaviruses: Andes virus (ANDV), Sin Nombre virus (SNV), and Hantaan virus (HTNV)

ABSTRACT: We report RNAseq analysis of control, calu3, astrocytes and cardiomyocytes cells under uninfected (mock) and Andes virus (ANDV), Sin Nombre virus (SNV), Hantaan virus (HTNV) infected and drug (synthetic 6AZA and Favipiravir, herbal Silymarin and Urolithin B) treated conditions

ORGANISM(S): Homo sapiens

PROVIDER: GSE232641 | GEO | 2024/05/16

REPOSITORIES: GEO

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Evaluating Differential Tropism, Pathogenesis, and Antiviral Agents of Hemorrhagic Fever Renal Syndrome and Cardiopulmonary Syndrome Causative Hantaviruses: Andes virus (ANDV), Sin Nombre virus (SNV), and Hantaan virus (HTNV)

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Project description:Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon stimulate genes (ISGs) play important roles in viral infection. However, the role of ISGs in HTNV infection is unclear. In this study, we observed the alteration of gene expression in HUVECs infected with HTNV compared with mock infected control and found considerable changes in mRNA and lncRNA profiles.

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