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Pol III transcribed genes, RNA-Seq, C.elegans

ABSTRACT: RNA-Seq of small (Pol III-transcribed) RNAs in worms, Pol III RNAi versus control

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE232720 | GEO | 2024/08/26

REPOSITORIES: GEO

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Project description:In budding yeast, the selective integration of the Ty1 LTR retrotransposon upstream of RNA polymerase III (Pol III)-transcribed genes requires the interaction between the AC40, a common subunit of Pol III and Pol I, and Ty1 integrase (IN1). The AC40/IN1 interaction involves a short sequence, the targeting domain (TD), present in the C-terminal part of IN1. Chip-seq analysis using WT or mutated Ty1 integrase demonstrated that TD is responsible for the recruitment of IN1 at both Pol I and Pol III-transcribed genes. Moreover, the introduction of the C-terminal residues of Ty1 in the Ty5 retrotransposon, which preferentially integrates in heterochromatin at silent mating loci (HMR and HML) and near telomeres, leads to its retargeting at Pol III-transcribed genes.

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