Transcriptomics

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ScRNA-seq data from two macaques in AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T-cells infected in vivo


ABSTRACT: Persistent HIV-1 reservoirs of infected CD4 T-cells are a major barrier to HIV-1 cure, though the mechanisms by which they are established and maintained in vivo remain poorly characterized. To study host properties that govern productive cellular infection, we analyzed viral mRNA+ (vRNA) CD4 T-cells of untreated SIV-infected macaques by single-cell RNAseq. Transcriptionally active infected cells, defined by spliced vRNA, were highly enriched for vRNA: 10.3% and 7.5% of all mRNA in two animals. These cells expressed diminished FOS, a component of the Activator protein 1 (AP-1) transcription factor, relative to vRNA-low and -negative cells.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE232998 | GEO | 2023/06/05

REPOSITORIES: GEO

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