Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

ABSTRACT: To further understand the impact of NeuroD1 on the global gene expression profile after MCAO

ORGANISM(S): Mus musculus

PROVIDER: GSE233213 | GEO | 2024/06/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

Project description:To further understand the impact of NeuroD1 on the endothelial cell gene expression profiles

2024-06-01 | GSE233329 | GEO

Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

Project description:Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

| PRJNA975473 | ENA

Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

Project description:Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke

| PRJNA975940 | ENA

Genome response to tissue plasminogen activator in experimental ischemic stroke

Project description:To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke. Forty-two Sprague-Dawley rats were subjected to: 2 hours of middle cerebral artery occlusion (MCAO); a permanent-MCAO; or were used as controls. tPA was administered to half of the rats in each group at 3hours. Whole blood was drawn at 24 hours, and isolated RNA levels measured on Affymetrix Rat Genome 230 2.0 GeneChip microarrays to examine the entire RNA transcriptome. 42 samples, 7 groups in total ( 2 treatmented disease, 2 untreated disease, and 3 control groups), each group had 6 replicates

2014-03-29 | E-GEOD-21136 | biostudies-arrayexpress

Genome response to tissue plasminogen activator in experimental ischemic stroke

2014-03-29 | GSE21136 | GEO

Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke.

Project description:The regenerative potential of brain has led to emerging therapies that can cure clinico-motor deficits after neurological diseases. Bone marrow mononuclear cell therapy is a great hope to mankind as these cells are feasible, multipotent and aid in neurofunctional gains in Stroke patients.This study evaluates safety, feasibility and efficacy of autologous mononuclear (MNC) stem cell transplantation in patients with chronic ischemic stroke (CIS) using clinical scores and functional imaging (fMRI and DTI).Non randomised controlled observational study Study: Twenty four (n=24) CIS patients were recruited with the inclusion criteria as: 3 months-2years of stroke onset, hand muscle power (MRC grade) at least 2; Brunnstrom stage of recovery: II-IV; NIHSS of 4-15, comprehendible. Fugl Meyer, modified Barthel Index (mBI) and functional imaging parameters were used for assessment at baseline, 8 weeks and at 24 weeks. Twelve patients were administered with mean 54.6 million cells intravenously followed by 8 weeks of physiotherapy. Twelve patients served as controls. All patients were followed up at 24 weeks.The laboratory and radiological outcome measures were within normal limits in MNC group. Only mBI showed statistically significant improvement at 24 weeks (p<0.05) whereas the mean FM, MRC, Ashworth tone scores in the MNC group were high as compared to control group. There was an increased number of cluster activation of Brodmann areas BA 4, BA 6 post stem cell infusion compared to controls indicating neural plasticity. Cell therapy is safe and feasible which may facilitate restoration of function in CIS.

| S-EPMC3908296 | biostudies-other

A NeuroD1 AAV-Based Gene Therapy For Functional Brain Repair After Ischemic Injury Through In Vivo Astrocyte-To-Neuron Conversion

Project description:NeuroD1-mediated in situ astrocyte-to-neuron conversion can regenerate a large number of functional new neurons after ischemic injury. RNA-sequencing was conducted to confirm neuronal recovery after cell conversion at the mRNA level.

2019-08-20 | GSE135981 | GEO

Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke

Project description:Here, we employed single-cell RNA sequencing (scRNA-seq) to comprehensively map the cell populations in the mouse model of MCAO (middle cerebral artery occlusion).

2021-09-24 | GSE174574 | GEO

CircRNA as Predictive Biomarker of Penumbra in Acute Ischemic Stroke

Project description:Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. By high-throughput sequencing of infarct and ischemic penumbra tissue from middle cerebral artery embolization (MCAO) mice, we identified the CircRNA expression was dramatically and selectively regulated in the penumbra tissues.

2022-11-01 | GSE186103 | GEO

The neurovascular unit-on-a-chip: modeling ischemic stroke to stem cell therapy.

Project description: Not available

| S-EPMC10883497 | biostudies-literature