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Transcriptional regulation of the germline piRNA pathway in the Drosophila ovary

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE233246 | GEO | 2024/12/23

REPOSITORIES: GEO

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A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-10 | E-GEOD-46101 | biostudies-arrayexpress

A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway

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2024-12-23 | GSE259366 | GEO

Transcriptional regulation of the germline piRNA pathway in the Drosophila ovary [RNA-seq]

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2024-12-23 | GSE233245 | GEO

Transcriptional regulation of the germline piRNA pathway in the Drosophila ovary [ATAC-seq]

Project description:The gene-regulatory mechanisms behind the female germline piRNA pathway in ovaries of metazoan species remain largely unexplored. Here, using the Drosophila model and combinations of RNA-seq, ATAC-seq, and single-cell approaches, we reveal the transcription factors that regulate the female germline piRNA pathway in animal ovaries.

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Somatic piRNA pathway prevents transgenerational germline transposition

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Transcriptional regulation of the germline piRNA pathway in the Drosophila ovary

Project description:Transcriptional regulation of the germline piRNA pathway in the Drosophila ovary

| PRJNA975551 | ENA

A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

Project description:The Drosophila piRNA pathway provides an RNA-based immune system that defends the germline genome against selfish genetic elements. Two interrelated branches of the piRNA system exist: somatic cells that support oogenesis only employ Piwi, whereas germ cells utilize a more elaborate pathway centered on the three gonad-specific Argonaute proteins (Piwi, Aubergine, and Argonaute 3). While several key factors of each branch have been identified, our current knowledge is insufficient to explain the complex workings of the piRNA machinery. Here, we report a reverse genetic screen spanning the ovarian transcriptome in an attempt to uncover the full repertoire of genes required for piRNA-mediated transposon silencing in the female germline. Our screen reveals key factors of piRNA-mediated transposon silencing, including the piRNA biogenesis factors CG2183 (GASZ) and Deadlock. Our data uncover a previously unanticipated set of factors preferentially required for repression of different transposon types.

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Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

Project description:In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi proteins. We find that distinct piRNA pathways with differing components function in ovarian germ and somatic cells. In the soma, Piwi acts singularly with the conserved flamenco piRNA cluster to enforce silencing of retroviral elements that may propagate by infecting neighboring germ cells. In the germline, silencing programs encoded within piRNA clusters are optimized via a slicer-dependent amplification loop to suppress a broad spectrum of elements. The classes of transposons targeted by germline and somatic piRNA clusters, though not the precise elements, are conserved among Drosophilids, demonstrating that the architecture of piRNA clusters has coevolved with the transposons that they are tasked to control.

| S-EPMC2882632 | biostudies-literature

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