Transcriptomics

Dataset Information

0

Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma [4NQOinDBLgata]


ABSTRACT: Eosinophils are present in several solid tumors and have context-dependent function. The role of eosinophils in the development of esophageal squamous cell cancer (ESCC), 85% of esophageal cancers worldwide, is unknown. Mice were treated with 4-nitroquinolone-1-oxide (4-NQO) for 8 weeks followed by vehicle for 8 weeks to induce esophageal squamous pre-cancer. Eosinophil depletion using three mouse models resulted in exacerbated 4-NQO tumorigenesis. RNA-sequencing on the whole esophagus of WT and ?dblGATA mice was done in the pre-cancer model to understand how the presence of eosinophils affects the pre-cancer esophageal environment.

ORGANISM(S): Mus musculus

PROVIDER: GSE233443 | GEO | 2023/12/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-12-01 | GSE233448 | GEO
2024-08-09 | GSE256088 | GEO
2014-07-01 | E-GEOD-54246 | biostudies-arrayexpress
2021-07-27 | PXD027596 | Pride
2022-11-01 | GSE202545 | GEO
2021-03-17 | GSE167366 | GEO
2021-03-17 | GSE167365 | GEO
2020-03-12 | GSE146808 | GEO
2023-12-01 | GSE233668 | GEO
2022-02-25 | GSE185070 | GEO