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Gene expression changes in collagen10a1 (col10a1) medaka mutants

ABSTRACT: To elucidate molecular mechanisms contributing to the disease phenotype in col10a1 medaka (Oryzias latipes) mutants, we isolated col10a1:nlGFP cells from heterozygous col10a1 medaka mutants and wild-type siblings via fluorescence activated cell sorting (FACS) and performed RNA-seq. Comparison of the transcriptome profiles indicated elevated ER stress, dysregulated cell polarity and reduced ECM production in heterozygous col10a1 mutants.

ORGANISM(S): Oryzias latipes

PROVIDER: GSE233581 | GEO | 2023/06/26

REPOSITORIES: GEO

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