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High CD44 expression identifies a quiescent/chemoresistant leukemic population with enhanced E-Selectin binding in T-ALL

ABSTRACT: We used single cell RNA sequencing (scRNA-seq) to decipher cell heterogeneity of human T-cell Acute Lymphoblastic Leukemia (M18) recovered from Bone Marrow Adipose Tissue (BMAT)-poor (Femur and Thoracic Vertebrae) and -rich (Tail Vertebrae) sites of xenografted immunodeficient mice (NSG,nonobese diabetic/severe combined immunodeficiency / interleukin-2Rγ null). We wanted to know whether some human T-ALL cells recovered in BMAT-poor sites resemble to those from BMAT-rich site.

ORGANISM(S): Homo sapiens

PROVIDER: GSE233600 | GEO | 2024/05/01

REPOSITORIES: GEO

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