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MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE233913 | GEO | 2024/09/30

REPOSITORIES: GEO

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MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [WT1-MAFB_ChIP-seq]

Project description:Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult.Loss of MafB led to the deposition of extracellular matrix, progressive foot process effacement, and kidney disease. mouse podocytes. Our data demonstrate open chromatin across podocyte specific genes and reveals that genes expressed in the mesoderm lineage become actively repressed upon podocyte differentiation. To better understand the transcriptional control of podocyte differentiation, we studied the role of transcription factor MAFB.

2024-09-30 | GSE233910 | GEO

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [MAFb KO RNA-seq]

2024-09-30 | GSE233912 | GEO

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [Histons modifications ChIP-seq]

2024-09-30 | GSE233911 | GEO

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters

Project description:MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters

| PRJNA978556 | ENA

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [WT1-MAFB_ChIP-seq]

Project description:MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [WT1-MAFB_ChIP-seq]

| PRJNA978561 | ENA

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [MAFb KO RNA-seq]

Project description:MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [MAFb KO RNA-seq]

| PRJNA978562 | ENA

MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [Histons modifications ChIP-seq]

Project description:MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [Histons modifications ChIP-seq]

| PRJNA978563 | ENA

Activation of podocyte Notch mediates early Wt1 glomerulopathy.

Project description:The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of scar tissue within glomeruli, the mechanisms of which are poorly understood. Here, we used a tamoxifen-based CRE-LoxP system to induce deletion of Wt1 in adult mice to investigate the mechanisms underlying evolution of glomerulosclerosis. Podocyte apoptosis was evident as early as the fourth day post-induction and increased during disease progression, supporting a role for Wt1 in mature podocyte survival. Podocyte Notch activation was evident at disease onset with upregulation of Notch1 and its transcriptional targets, including Nrarp. There was repression of podocyte FoxC2 and upregulation of Hey2 supporting a role for a Wt1/FoxC2/Notch transcriptional network in mature podocyte injury. The expression of cleaved Notch1 and HES1 proteins in podocytes of mutant mice was confirmed in early disease. Furthermore, induction of podocyte HES1 expression was associated with upregulation of genes implicated in epithelial mesenchymal transition, thereby suggesting that HES1 mediates podocyte EMT. Lastly, early pharmacological inhibition of Notch signaling ameliorated glomerular scarring and albuminuria. Thus, loss of Wt1 in mature podocytes modulates podocyte Notch activation, which could mediate early events in WT1-related glomerulosclerosis.

| S-EPMC6169130 | biostudies-literature

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-04 | GSE154956 | GEO

Transcriptome profile of MafB-cKO of podocyte

Project description:The transcription factor MafB is essential for differentiation and foot process formation of podocytes. In order to identify the downstream targets of MafB, we analyzed the Mafb-deficient podocyte by RNA-seq. We found slit diaphragm-related protein (Nphs1, Magi2), Rho GTPase-activating protein (Arhgap24, Iqgap2) and podocyte-specific transcription factor (Tcf21) were significantly reduced in MafB cKO glomeruli. This indicates that one of these factors might be directly regulated by MafB to maintain its function in podocyte maintenance.

2021-08-03 | GSE96044 | GEO

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