Genomics

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Control of Embryonic Brown Adipocyte Development by GATA6 [ChIP-Seq]


ABSTRACT: Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic brown fat progenitor cells and regulators of adipogenic commitment are unclear. We identified the transcription factor GATA6 as a selective marker of brown adipogenic progenitor cells. Deletion of Gata6 in the brown fat lineage resulted in a striking loss of BAT. To gain insight into the mechanism by which GATA6 supports BAT development, we performed ChIP-seq for GATA6 from the BAT of embryonic day 15.5 embryos.

ORGANISM(S): Mus musculus

PROVIDER: GSE234012 | GEO | 2023/07/19

REPOSITORIES: GEO

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