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RNA sequencing of spheroids from HUVECs for differences in Cis- and Trans-signaling of IL-11

ABSTRACT: Cytokines of the IL-6 family, such as IL-11, may influence angiogenesis. Our experiments showed opposite angiogenic effects on HUVECs depending on cis- or transsignaling of IL-11. Spheroids from the 3D angiogenesis model (spheroid sprouting assay) were lysed in QIAzole buffer by vigorous vortexing. The transcriptomic changes were analyzed by RNA sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234142 | GEO | 2024/09/20

REPOSITORIES: GEO

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