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Effect of Gemcitabine and nab-paclitaxel in pancreatic cancer cachexia

ABSTRACT: The aim of the study is to test if Gemcitabine in combination with nab-paclitaxel can prevent muscle wasting and cardiac dysfunction in a mouse model of pancreatic cancer cachexia.

ORGANISM(S): Mus musculus

PROVIDER: GSE234545 | GEO | 2025/04/04

REPOSITORIES: GEO

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Effect of Gemcitabine and nab-paclitaxel in pancreatic cancer cachexia

Project description:Effect of Gemcitabine and nab-paclitaxel in pancreatic cancer cachexia

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Project description:Metastatic pancreatic cancer is difficult to treat. Until recently, most patients would be offered treatment with a chemotherapy drug called gemcitabine. However, a large international trial showed that combining gemcitabine with a drug called nab-paclitaxel (or abraxane) was more effective compared with gemcitabine alone. The purpose of this study is to compare two different ways of combining gemcitabine with abraxane. Conventionally, both drugs are given on the same day via a drip into a vein in the arm but research suggests that giving abraxane 24 hours in advance of gemcitabine could possibly be more beneficial. In this study, blood and tumour samples will be collected and analysed to try to confirm what has been seen in the laboratory studies. In addition, the investigators wish to find out whether certain tumour characteristics (called biomarkers) can be used to predict for response to chemotherapy.

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A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells.

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