Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [human]

ABSTRACT: Performed transcriptomic analysis of BRAF K499E homozygous and wildtype organoid to investigate the molecular basis of BRAF K499E-induced learning and memory deficits.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234548 | GEO | 2025/03/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse]

Project description:Performed transcriptomic analysis of Nestin;BrafKE/+ and Braf+/+ mice to investigate the molecular basis of BRAF K499E-induced learning and memory deficits.

2025-03-21 | GSE234763 | GEO

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse_BRAF K499E]

Project description:Performed transcriptomic analysis of BRAF K499E-transfected astrocytes to investigate the molecular basis of BRAF K499E-induced learning and memory deficits.

2025-03-21 | GSE283653 | GEO

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-21 | GSE234764 | GEO

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis

Project description:Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis

| PRJNA982867 | ENA

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse]

Project description:Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse]

| PRJNA982869 | ENA

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [human]

Project description:Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [human]

| PRJNA982028 | ENA

Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse_BRAF K499E]

Project description:Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis [mouse_BRAF K499E]

| PRJNA1194986 | ENA

Oncogenic KRAS(G12V) and BRAF(V600E) in intestinal organoids

Project description:Goals of the study was to compare transcripional and phenotypic response of mouse intestinal organoid cultures to the KRAS(G12V) or BRAF(V600E)oncogenes.

2018-06-02 | GSE115234 | GEO

HDX-MS data on bRaf, bRaf/Cdc37 and bRaf/Cdc37/Hsp90 protein complexes

Project description:HDX-MS data on bRaf, bRaf/Cdc37 and bRaf/Cdc37/Hsp90 protein complexes

2022-01-04 | MSV000088635 | MassIVE

Complement C3 released from neurotoxic reactive astrocytes impairs learning and memory in the mouse model of postoperative neurodegenerative disorders

Project description:Perioperative neurocognitive disorder (PNDs) can commonly occur after major surgery in at risk patients and its occurrence increases medical healthcare burdens and even mortality. Accumulating evidence points to neuroinflammation being pivotal to the pathogenesis of these conditions. The complement cascade contributes to neuroinflammatory responses in the central nervous system (CNS) and complement C3 has been implicated in the manifestation of cognitive deficits in several neurological conditions. Neurotoxic reactive astrocytes function differently to their non-activated counterparts and release complement components in response to pathological triggers. We observed previously that surgery induces a rapid rise and then fall in cytokines but a more sustained glial activation response that coincided with postoperative cognitive impairment. In this study, we explored the relationship between the expression of complement C3, glial activation, and cognitive deficits. Using a murine model of surgery, we characterized the transcriptional profiles of hippocampal astrocytes after surgery and examined the effects of C3 suppression on the neuroinflammatory response and cognitive performance. There was a delayed but sustained rise in hippocampal C3 of astrocytic in origin after surgery which corresponded with the onset of cognitive decline. Furthermore, the A1 or the neurotoxic phenotype predominated in this postoperative astrocytic activation, and these cells have a distinct transcriptional profile including C3 upregulation. Suppression of C3 inhibited synaptic phagocytosis by microglia and attenuated postoperative cognitive impairment. Therefore, C3 from reactive astrocytes appear central to the development of cognitive dysfunction associated with postoperative neuroinflammation.

2024-03-13 | GSE199318 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data