The transcriptional alteration and non-invasive biomarker potential of peripheral blood microRNAs in patients with early-onset pre-eclampsia
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ABSTRACT: Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with significant maternal and fetal morbidity and mortality. Currently, there is a critical need for accurate, non-invasive biomarkers to facilitate early diagnosis and effective management of EOPE. In this study, we aimed to investigate the transcriptional alterations and non-invasive biomarker potential of peripheral blood microRNAs in patients with EOPE. Through our research, we successfully identified two reliable plasma miRNA biomarkers and proposed a circulating two-miRNA panel for the non-invasive early detection of EOPE. Additionally, we independently validated our findings in different patient cohorts using various technological platforms.
ORGANISM(S): Homo sapiens
PROVIDER: GSE234611 | GEO | 2023/06/14
REPOSITORIES: GEO
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