Other

Dataset Information

0

Whole exome sequencing of HNSCC PDX with KMT2D-inactivating mutation


ABSTRACT: Histone H3 lysine (H3K4) methyltransferase KMT2D is a key regulator of gene expression, mainly through promoting H3K4 methylation and activating enhancers, and plays critical roles in development, differentiation, metabolism, and tumor suppression. Our study found that KMT2D-deficient HNSCC is sensitive to 2-DG plus DNA damage agents or 2-DG plus PAPR inhibitors in HNSCC mouse models and human cell lines. To further investigate the therapeutic potential of these treatments, we aimed to use patient-derived xenograft (PDX) with MT2D-inactivating utations. We sequenced one PDX from the University of Colorado School of Medicine by whole exome sequencing which has the nonsense mutation of KMT2D.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234824 | GEO | 2024/07/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-07-01 | GSE237454 | GEO
2024-07-01 | GSE234640 | GEO
2022-10-06 | GSE185537 | GEO
2022-10-06 | GSE185535 | GEO
2022-10-06 | GSE185536 | GEO
2015-08-28 | E-GEOD-67314 | biostudies-arrayexpress
2019-02-07 | GSE126164 | GEO
2016-01-28 | GSE75151 | GEO
2024-05-07 | MSV000094701 | MassIVE
2018-10-23 | GSE94816 | GEO