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Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234856 | GEO | 2023/06/14

REPOSITORIES: GEO

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Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [II]

Project description:NanoString based gene expression data from skin biopsies from nine mycosis fungoides patients before and after phototherapy as well as four healthy donor skin as a comparator

2023-06-14 | GSE234854 | GEO

Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [I]

Project description:NanoString based gene expression data from skin biopsies from nine mycosis fungoides patients before and after phototherapy as well as four healthy donor skin as a comparator

2023-06-14 | GSE234852 | GEO

Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides

Project description:Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides

| PRJNA983340 | ENA

Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [II]

Project description:Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [II]

| PRJNA983348 | ENA

Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [I]

Project description:Phototherapy restores deficient type I interferon production and enhances antitumor responses in mycosis fungoides [I]

| PRJNA983343 | ENA

Interventions for mycosis fungoides.

Project description: Not available

| S-EPMC7389258 | biostudies-literature

Mycosis fungoides

Project description:Mycosis fungoides (MF) is the most common and best studied of cutaneous T-cell lymphoma (CTCL). Three clinical cutaneous stages have been described (patch, plaque and tumor) as the disease progress developing also the disease lymph node, peripheral blood or systemic involvement in late stages. Clinical and pathologic diagnosis of early MF stages (patch and plaque) is difficult as its morphologic similarity to inflammatory dermatoses and low proportion of tumoral cells.

2018-06-21 | GSE109421 | GEO

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients.

Project description:Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin's lymphomas. HMF has a unique set of defining features that include light colored to achromic lesions, a predilection for darker skin phototypes, an early onset of disease, and predominance of CD8+ T-cells, among others. In the current review, we detail the known pathways of molecular pathogenesis for this lymphoma and posit that an active Th1/cytotoxic antitumor immune response in part explains why this variant is primarily seen in children/adolescents and young adults, who do not exhibit signs of immunosenescence. As a result of this potent cytotoxic response, HMF patients experience mostly favorable overall prognosis, while hypopigmentation may in fact represent a useful surrogate marker of cytotoxic immunity targeting the malignant cells. Understanding the molecular processes behind the specific features that define HMF may lead to improved diagnostic accuracy, personalized prognosis by risk stratification, and improved management of HMF. Moreover, improving our knowledge of HMF may aid our further understanding of other cutaneous lymphomas.

| S-EPMC7465783 | biostudies-literature

Mycosis fungoides

Project description:Mycosis fungoides

| PRJNA430861 | ENA

The Neoantigen Landscape of Mycosis Fungoides.

Project description:BackgroundMycosis fungoides (MF) is the most common cutaneous T-cell lymphoma, for which there is no cure. Immune checkpoint inhibitors have been tried in MF but the results have been inconsistent. To gain insight into the immunogenicity of MF we characterized the neoantigen landscape of this lymphoma, focusing on the known predictors of responses to immunotherapy: the quantity, HLA-binding strength and subclonality of neoantigens.MethodsWhole exome and whole transcriptome sequences were obtained from 24 MF samples (16 plaques, 8 tumors) from 13 patients. Bioinformatic pipelines (Mutect2, OptiType, MuPeXi) were used for mutation calling, HLA typing, and neoantigen prediction. PhyloWGS was used to subdivide malignant cells into stem and clades, to which neoantigens were matched to determine their clonality.ResultsMF has a high mutational load (median 3,217 non synonymous mutations), resulting in a significant number of total neoantigens (median 1,309 per sample) and high-affinity neoantigens (median 328). In stage I disease most neoantigens were clonal but with stage progression, 75% of lesions had >50% subclonal antigens and 53% lesions had CSiN scores <1. There was very little overlap in neoantigens across patients or between different lesions on the same patient, indicating a high degree of heterogeneity.ConclusionsThe neoantigen landscape of MF is characterized by high neoantigen load and significant subclonality which could indicate potential challenges for immunotherapy in patients with advanced-stage disease.

| S-EPMC7719792 | biostudies-literature

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