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The role of IL-6 and IL-27 signalling on virus specific CD4 T cell responses during LCMV Cl13 infection

ABSTRACT: LCMV Clone 13 is an arenavirus that results in a persistent viral infection in mice when delivered intravenously. It has been widely used to explore the impact of chronic viral infection on CD4 T cell responses and dissect mechanisms that regulate this. In this study we used mixed bone marrow chimeras from wildtype and cytokine reeptor deficient (gp130 or IL-6/IL-27R) mice to determine the role these cytokines on splenic CD4 T cell responses 30 days post infection

ORGANISM(S): Mus musculus

PROVIDER: GSE235035 | GEO | 2023/07/15

REPOSITORIES: GEO

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