Transcriptomics

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Effect of cholesterol overload on gene expression of RAW264 macrophages


ABSTRACT: Hepatocyte death plays a critical role in the disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH). We have previously reported that hepatocyte death locally induces phenotypic changes in the macrophages surrounding the corpse and remnant lipids, thereby promoting liver fibrosis in a murine model of NASH. Here, we demonstrated free cholesterol was accumulated in macrophages around dead hepatocytes containing cholesterol crystals. In vitro experiments revealed that cholesterol-induced lysosomal stress triggered profibrotic activation in macrophages. This study provides evidence that dysregulated cholesterol metabolism in macrophages would be a novel mechanism of NASH.

ORGANISM(S): Mus musculus

PROVIDER: GSE235222 | GEO | 2023/06/25

REPOSITORIES: GEO

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