Hippocampal single-nuclei RNA-sequencing identifies a role for Kdm5a in regulating cell identity
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ABSTRACT: KDM5A is a chromatin remodeler disrupted in neurodevelopmental disease. To investigate the effect of losing KDM5A on the development of the hippocampus, we profiled hippocampi from wild type (WT) and Kdm5a -/- mice using single-nuclei RNA sequencing (snRNA-seq). We found that KDM5A regulates the development of specific subtypes of excitatory (CA1, CA2, CA3) and inhibitory (SST+, PVALB+) neurons, that loss of KDM5A leads to a more mature cellular identity in the hippocampus, and that KDM5A functions early in development to specify proper CA1 cell identity.
ORGANISM(S): Mus musculus
PROVIDER: GSE235490 | GEO | 2023/09/01
REPOSITORIES: GEO
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