Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE235665 | GEO | 2024/04/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

DNA methylation in Crohns' disease and ulcerative colitis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-12-19 | E-GEOD-32149 | biostudies-arrayexpress

Ulcerative Colitis subjects

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-04-01 | GSE107597 | GEO

DNA methylation in Crohns' disease and ulcerative colitis

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-12-19 | GSE32149 | GEO

Comprehensive transcriptome profiling of ulcerative colitis mouse model suggests biomarkers and therapeutic targets for human colitis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-13 | GSE155303 | GEO

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans. [scRNAseq_MouseLPL]

Project description:To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in animal models of diabetes and other contexts. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients. Furthermore, TCR sequence analysis indicated stem-like T cells were clonally related to pro-inflammatory T cells, suggesting their involvement in sustaining effectors that drive inflammation. Using an adoptive transfer colitis model, we demonstrated that CD4+ T cells deficient in BCL-6, a transcription factor promoting T cell stemness, had decreased colon T cells, reduced TH17 cells, and diminished pathogenicity. Our results establish a strong association between stem-like T cell populations and UC pathogenesis, highlighting the potential of targeting this population to improve clinical outcomes.

2024-04-24 | GSE264530 | GEO

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [bulkRNAseq_MouseLPL]

2024-04-24 | GSE264463 | GEO

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [scRNAseq_Mouse]

Project description:To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ 32 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in animal models of diabetes and other contexts. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients. Furthermore, TCR sequence analysis indicated stem-like T cells were clonally related to pro-inflammatory T cells, suggesting their involvement in sustaining effectors that drive inflammation. Using an adoptive transfer colitis model, we demonstrated that CD4+ 38 T cells deficient in BCL-6, a transcription factor promoting T cell stemness, had decreased colon T cells, reduced TH17 cells, and diminished pathogenicity. Our results establish a strong association between stem-like T cell populations and UC pathogenesis, highlighting the potential of targeting this population to improve clinical outcomes.

2024-04-24 | GSE235664 | GEO

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [scRNAseq_Human]

Project description:To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ 32 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in animal models of diabetes and other contexts. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients. Furthermore, TCR sequence analysis indicated stem-like T cells were clonally related to pro-inflammatory T cells, suggesting their involvement in sustaining effectors that drive inflammation. Using an adoptive transfer colitis model, we demonstrated that CD4+ 38 T cells deficient in BCL-6, a transcription factor promoting T cell stemness, had decreased colon T cells, reduced TH17 cells, and diminished pathogenicity. Our results establish a strong association between stem-like T cell populations and UC pathogenesis, highlighting the potential of targeting this population to improve clinical outcomes.

2024-04-24 | GSE235663 | GEO

Mucosal expression profiling in (un)inflamed colon of patients with ulcerative colitis (UC)

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-01-01 | GSE48959 | GEO

Function of BRG1 in colitis and colitis-associated-cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-03-01 | GSE112128 | GEO