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Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE235827 | GEO | 2024/12/31

REPOSITORIES: GEO

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Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [III]

Project description:Purpose: RNA-seq analysis of gene expression patterns in Naïve t, Th0, Treg and Th17 cells of wild-type mice. The goals of this study are to compared the gene expression between Naïve T and other types Th cells by RNA-seq analysise.

2024-12-31 | GSE235823 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

Project description:Purpose: RNA-seq analysis of gene expression in Th0 cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Th0 cells by RNA-seq analysise.

2024-12-31 | GSE235822 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

Project description:Purpose: RNA-seq analysis of gene expression in Th17 cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Th17 cells by RNA-seq analysise.

2024-12-31 | GSE235826 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

Project description:Purpose: RNA-seq analysis of gene expression in Treg cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Treg cells by RNA-seq analysise.

2024-12-31 | GSE235825 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

| PRJNA987673 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

| PRJNA987678 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

| PRJNA987681 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

| PRJNA987680 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [III]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [III]

| PRJNA987679 | ENA

Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling.

Project description:Coordinated metabolic reprogramming and epigenetic remodeling are critical for modulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obscure. Here, we find that Setd2, a histone H3K36 trimethyltransferase, suppresses Th17 development but promotes iTreg cell polarization via phospholipid remodeling. Mechanistically, Setd2 up-regulates transcriptional expression of lysophosphatidylcholine acyltransferase 4 (Lpcat4) via directly catalyzing H3K36me3 of Lpcat4 gene promoter in T cells. Lpcat4-mediated phosphatidylcholine PC(16:0,18:2) generation in turn limits endoplasmic reticulum stress and oxidative stress. These changes decrease HIF-1α transcriptional activity and thus suppress Th17 but enhance Treg development. Consistent with this regulatory paradigm, T cell deficiency of Setd2 aggravates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis due to imbalanced Th17/Treg cell differentiation. Overall, our data reveal that Setd2 acts as an epigenetic brake for T cell-mediated autoimmunity through phospholipid remodeling, suggesting potential targets for treating neuroinflammatory diseases.

| S-EPMC10895270 | biostudies-literature

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