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Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE236151 | GEO | 2023/10/22

REPOSITORIES: GEO

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Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation.

Project description:Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator and an essential role for KLF2+ CD4 cells in averting microbiota-driven intestinal inflammation. CD4 cells with commensal specificity in secondary lymphoid organs and intestinal tissues are enriched for KLF2 expression, and distinct from FOXP3+ regulatory T cells or other differentiation lineages. Mice with conditional KLF2 deficiency in T cells develop spontaneous rectal prolapse and intestinal inflammation, phenotypes overturned by eliminating microbiota or reconstituting with donor KLF2+ cells. Activated KLF2+ cells selectively produce IL-10, and eliminating IL-10 overrides their suppressive function in vitro and protection against intestinal inflammation in vivo. Together with reduced KLF2+ CD4 cell accumulation in Crohn's disease, a necessity for the KLF2+ subpopulation of T regulatory type 1 (Tr1) cells in sustaining commensal tolerance is demonstrated.

| S-EPMC10822050 | biostudies-literature

Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [Fluidgm]

Project description:Commensal immune tolerance requires cells that actively sense and suppress inflammation. To understand how commensal tolerance works, mice colonized with recombinant Candida albicans expressing model MHC II peptide 2W1S were used to track CD4 cells with surrogate commensal specificity by tetramer staining and enrichement. Interestingly, half of the commensal CD4 cell lack expression of established T helper lineage defining transcription markers after intranuclear staining and flow cytometry. To more comprehensively investigate commensal cells, FACS sorted commensal CD4 cells with commensal specificity were analysed individually using single cell RNA sequencing.

2023-10-22 | GSE236150 | GEO

Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [RNA-seq]

Project description:Commensal immune tolerance requires cells that actively sense and suppress inflammation. Here we show this is in large part mediated by CD4 cells that express the transcriptional regulator KLF2. Suppression by KLF2+ CD4 cells requires cell-intrinsic TCR stimulation. To investigate how KLF2 CD4 cells perform this role, gene expression by purified KLF2+ compared with KLF2-negative CD4 cells were evaluated with TCR stimulation in vitro and control non-stimulated cells.

2023-10-22 | GSE236148 | GEO

Interplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-02-12 | E-GEOD-47736 | biostudies-arrayexpress

Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation

Project description:Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation

| PRJNA989136 | ENA

Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [Fluidgm]

Project description:Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [Fluidgm]

| PRJNA989139 | ENA

The intestinal microbiota programs DNA methylation to control tissue homeostasis and inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-06 | GSE137037 | GEO

Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [RNA-seq]

Project description:Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [RNA-seq]

| PRJNA989140 | ENA

Altered epigenetic programming links intestinal inflammation to colon cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-17 | E-GEOD-57569 | biostudies-arrayexpress

Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-27 | GSE90462 | GEO

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