Transcriptomics

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Tumor-specific activation of folate receptor beta and its use in reprogramming the tumor microenvironment


ABSTRACT: Folate-TLR7 agnost was designed to reprogram the FRβ-expressing TAMs/MDSCs in the tumor microenvironemt. We used single cell RNAseq to demonstrate that this selective repolarization of myeloid cells in solid tumors not only changes their properties towards a less immunosuppressive phenotype, but also induces a general proinflammatory transition throughout the entire tumor mass.

ORGANISM(S): Mus musculus

PROVIDER: GSE236443 | GEO | 2024/02/28

REPOSITORIES: GEO

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