Tumor-specific activation of folate receptor beta and its use in reprogramming the tumor microenvironment
Ontology highlight
ABSTRACT: Folate-TLR7 agnost was designed to reprogram the FRβ-expressing TAMs/MDSCs in the tumor microenvironemt. We used single cell RNAseq to demonstrate that this selective repolarization of myeloid cells in solid tumors not only changes their properties towards a less immunosuppressive phenotype, but also induces a general proinflammatory transition throughout the entire tumor mass.
ORGANISM(S): Mus musculus
PROVIDER: GSE236443 | GEO | 2024/02/28
REPOSITORIES: GEO
ACCESS DATA