Transcriptomics

Dataset Information

0

Global transcriptomic profiling of permanent focal ischemia in an in vivo rat model


ABSTRACT: Focal ischemia is triggered by the sudden significant reduction of blood supply to the brain, as a result of either the rupture or occlusion by thrombus/embolism of a blood vessel in the brain. Permanent focal ischemia occurred when blood supply to a specific part of the brain is impeded without reperfusion. Despite major steps achieved in the elucidation of the patho-physiology of cerebral ischemia, the available therapeutic avenues for acute ischemic stroke remain scarce. Cell cycle re-activation has been revealed as a novel signaling pathway during permanent focal ischemia. As such, non-specific aurora kinase inhibitor ZM447439, has been injected intracranial-ventricularly30min post-ischemia induction to determine its efficacy in reduction of neuronal damage in terms of infarct volume.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE23651 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA142705

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-12-31 | GSE25556 | GEO
2013-12-31 | E-GEOD-23651 | biostudies-arrayexpress
2013-12-31 | E-GEOD-25556 | biostudies-arrayexpress
2009-03-07 | E-TABM-655 | biostudies-arrayexpress
2019-10-08 | GSE107452 | GEO
2021-01-01 | E-MTAB-9935 | biostudies-arrayexpress
2017-02-28 | E-MTAB-4658 | biostudies-arrayexpress
2022-10-10 | GSE160030 | GEO
2023-09-21 | E-MTAB-11967 | biostudies-arrayexpress
2019-11-07 | GSE138805 | GEO