Global transcriptomic profiling of permanent focal ischemia in an in vivo rat model
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ABSTRACT: Focal ischemia is triggered by the sudden significant reduction of blood supply to the brain, as a result of either the rupture or occlusion by thrombus/embolism of a blood vessel in the brain. Permanent focal ischemia occurred when blood supply to a specific part of the brain is impeded without reperfusion. Despite major steps achieved in the elucidation of the patho-physiology of cerebral ischemia, the available therapeutic avenues for acute ischemic stroke remain scarce. Cell cycle re-activation has been revealed as a novel signaling pathway during permanent focal ischemia. As such, non-specific aurora kinase inhibitor ZM447439, has been injected intracranial-ventricularly30min post-ischemia induction to determine its efficacy in reduction of neuronal damage in terms of infarct volume.
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE23651 | GEO | 2013/12/31
SECONDARY ACCESSION(S): PRJNA142705
REPOSITORIES: GEO
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