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Effect of knockdown of KAT7 on gene expression in HCT116 cell line.

ABSTRACT: Accurate centriole formation is critical for cell replication. However, the holistic transcriptional regulatory mechanisms involved in this process remain elusive.We report here that KAT7 histone acetyltransferase is a key regulatory molecule that regulates centriole replication. Knockdown of KAT7 leads to reduced levels of histone H3K14 acetylation and reduced enrichment of H3K14ac in the promoter region of centriole formation-related genes, resulting in blocked centriole formation. Our data provide a new insight for the role of histone modifying factors in centriole replication-related pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE236701 | GEO | 2024/10/13

REPOSITORIES: GEO

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Stem cell plasticity, acetylation of H3K14 and de novo gene activation rely on KAT7

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