Transcriptomics

Dataset Information

0

Loss of Kindlin-1 drives a more aggressive phenotype in cutaneous squamous cell carcinoma


ABSTRACT: Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous squamous cell carcinoma (SCC). In this study, we show that loss of Kindlin-1 in a mouse model of cutaneous SCC leads to increased migration, invasion and degradation of collagen. Loss of Kindlin-1 increased tumor growth in vivo and in 3D spheroids, which was associated with the development of a hypoxic tumor environment and increased glycolysis. One of the most highly upregulated genes in Kindlin-1-depleted tumors was Mmp13, and the increased expression of MMP13 was responsible for driving the increased migration and invasion of the Kindlin-1-depleted SCC cells. These results provide evidence that Kindlin-1 loss in SCC can promote migration and invasion through the upregulation of MMP13, and offer novel insights into how Kindlin-1 loss leads to the development of a hypoxic environment that is permissive for tumor growth.

ORGANISM(S): Mus musculus

PROVIDER: GSE236883 | GEO | 2023/07/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-04-30 | E-GEOD-42677 | biostudies-arrayexpress
2013-04-30 | GSE42677 | GEO
2017-04-19 | GSE97951 | GEO
2018-08-25 | GSE87841 | GEO
2020-12-01 | GSE123438 | GEO
| PRJNA992569 | ENA
2020-10-01 | GSE150291 | GEO
2015-12-16 | E-GEOD-76020 | biostudies-arrayexpress
2023-03-07 | GSE222028 | GEO
2021-07-28 | PXD026264 | Pride