Transcriptomics

Dataset Information

0

Too much of a good thing: Extended duration of gut microbiota depletion reverses protection from experimental autoimmune uveitis


ABSTRACT: Microbial sequencing revealed progressive reduction of gut microbiota that showed some differences in the two ABX groups compared to untreated controls. Interestingly, duration of ABX was associated with a gradual disappearance of the CD4+ and CD4+CD8+ subset of gut intraepithelial lymphocytes (IELs). This IEL subset is microbiota-dependent and is absent in germ-free mice. Relative abundance of Lactobacillus reuteri correlated with frequencies of CD4+CD8+ IELs and reduced EAU. Notably, IELs in culture suppressed antigen-specific activation of autoreactive T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE236922 | GEO | 2023/11/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-09-10 | GSE213034 | GEO
2015-01-26 | E-GEOD-60566 | biostudies-arrayexpress
2020-11-03 | GSE160628 | GEO
2020-11-05 | GSE148127 | GEO
2024-10-22 | GSE279876 | GEO
2015-01-26 | GSE60566 | GEO
2020-07-15 | GSE154428 | GEO
2021-10-25 | GSE185407 | GEO
2022-11-01 | GSE200025 | GEO
2021-07-23 | GSE152316 | GEO