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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE236972 | GEO | 2023/07/11

REPOSITORIES: GEO

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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5 [4T1 tumors]

Project description:Breast cancer cells or tumors underwent RNA-sequencing or single cell RNA-sequencing to study the role of HSF1 in tumor-immune interactions.

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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5 [4T1]

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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5

Project description:HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5

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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5 [4T1 tumors]

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Project description:HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5 [4T1]

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Project description:HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5 [MDA-MB-231]

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Project description:Over half of breast-cancer-related deaths are due to recurrence 5 or more years after initial diagnosis and treatment. This latency suggests that a population of residual tumor cells can survive treatment and persist in a dormant state for many years. The role of the microenvironment in regulating the survival and proliferation of residual cells following therapy remains unexplored. Using a conditional mouse model for Her2-driven breast cancer, we identify interactions between residual tumor cells and their microenvironment as critical for promoting tumor recurrence. Her2 downregulation leads to an inflammatory program driven by TNFα/NFκB signaling, which promotes immune cell infiltration in regressing and residual tumors. The cytokine CCL5 is elevated following Her2 downregulation and remains high in residual tumors. CCL5 promotes tumor recurrence by recruiting CCR5-expressing macrophages, which may contribute to collagen deposition in residual tumors. Blocking this TNFα-CCL5-macrophage axis may be efficacious in preventing breast cancer recurrence.

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ADAM9 Up-regulates N-Cadherin via MiR-218 Suppression in Lung Adenocarcinoma Cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Neuroblastoma differentiation in vivo excludes cranial tumors.

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