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Heme exposure induces the phenotype of Hmox1high, Marcohigh, and MHC class IIlow macrophages

ABSTRACT: Bulk RNA sequencing revealed that heme exposure induced the phenotype of Hmox1high, Marcohigh, and MHC class IIlow macrophages, demonstrating a strong expression of NRF2-regulated. However, these cells showed weak expression of the TAM marker genes Arg1 and Spp1, indicating that heme treatment alone was insufficient to induce the full heme-TAM phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE237238 | GEO | 2024/01/03

REPOSITORIES: GEO

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Heme exposure induces the phenotype of Hmox1high, Marcohigh, and MHC class IIlow macrophages

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