Transcriptomics

Dataset Information

0

Role of PLK1 in epithelial-mesenchymal transition in human melanoma


ABSTRACT: Polo-like kinase 1 (PLK1), a serine/threonine kinase and important cell cycle regulator, is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB, a NOTCH antagonist. However, the exact role of PLK1-NUMB-NOTCH axis in epithelial-mesenchymal transition (EMT) and melanoma progression is unclear. In this study, Affymetrix microarray analysis was performed to determine differentially expressed genes following doxycyclin induced shRNA-mediated knockdown of PLK1 in human melanoma cells that showed significant modulations in EMT and metastasis related genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE237385 | GEO | 2024/01/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-10-07 | GSE159095 | GEO
2023-10-22 | GSE241973 | GEO
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
2023-10-02 | GSE228155 | GEO
2021-08-26 | PXD022410 | Pride
2024-05-28 | GSE264739 | GEO
2023-12-19 | GSE250059 | GEO
2024-11-01 | PXD053933 | Pride
2013-07-31 | GSE30669 | GEO
2015-03-21 | GSE67102 | GEO