Transcriptomics

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Expression data from untreated and rottlerin-treated normal and systemic sclerosis-derived human fibroblasts


ABSTRACT: PKC-δ inhibition with the selective inhibitor, rottlerin, resulted in potent downregulation of type I collagen expression and production in normal human dermal fibroblasts and abrogated the exaggerated type I collagen production and expression in fibroblasts cultured from affected skin from patients with the fibrosing disorder, systemic sclerosis (SSc). To elucidate the mechanisms involved in the ability of PKC-δ to regulate collagen production in fibroblasts, we examined the effects of PKC-δ inhibition on the transcriptome of normal and SSc-derived human dermal fibroblasts. We used microarrays to detail the effects of PKC-δ inhibition with rottlerin on the transcriptome of normal and SSc-derived human dermal fibroblasts and to identify gene networks that might be involved in the regulation of extracellular matrix by PKC-δ.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23741 | GEO | 2010/08/22

SECONDARY ACCESSION(S): PRJNA130767

REPOSITORIES: GEO

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