Transcriptomics

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Effect of imatinib on philadelphia chromosome positive acute lymphoblastic leukemia


ABSTRACT: The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. In this study, the tyrosine kinase inhibitor imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of Ph+ ALL cell lines were analyzed in response to imatinib treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23743 | GEO | 2010/09/10

SECONDARY ACCESSION(S): PRJNA130771

REPOSITORIES: GEO

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