Transcriptomics

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Characterisation of the molecular signature of an 8 week-old human embryonic notochord


ABSTRACT: During embryonic development, the notochord is the precursor to the nucleus pulposus (NP) in the intervertebral disc (IVD), where the notochord cells differentiate to become notochordal-like cells in the NP, and are considered as potential progenitor cells to support the function of the NP. With aging and degeneration, there is a loss of these cells from the NP which ultimately affects IVD function. The characterisation of the molecular signature of the 8 week-old (gestational age) human embryonic notochord is a valuable resource to better understand the development from the notochord to the NP progenitors and as a benchmark for comparison to other datasets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE237542 | GEO | 2023/11/11

REPOSITORIES: GEO

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