Transcriptomics

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LPS-induced gene expression in mouse small intestinal epithelial cells


ABSTRACT: Intestinal epithelial cells express the lipopolysaccharide (LPS) receptor Toll-like receptor (TLR4) and are responsive to LPS stimulation. Following LPS exposure, epithelial cells, similar to myeloid cells such as macrophages, acquire a state of tolerance. Innate immune tolerance is characterized by a lack of expression of proinflammatory genes in response to repeated stimulation. Tolerant epithelial cells, however, exhibit sustained expression of a distinct set of genes encoding for proteins involved in metabolism and homeostasis. This study comparatively analyzes the gene expression profile 6 hours after LPS stimulation (acute response) versus 6 hours LPS followed by 90 hours incubation in the absence of LPS (tolerant response).

ORGANISM(S): Mus musculus

PROVIDER: GSE23755 | GEO | 2010/08/29

SECONDARY ACCESSION(S): PRJNA130745

REPOSITORIES: GEO

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