Genomics

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The transcriptional landscape associated with the deletion of Regnase-1 [ATAC-Seq]


ABSTRACT: Having identified the crucial role of IFN-γ in anti-tumor immunity of Reg-1ΔNK, we attempted to elucidate the mechanism underlying the regulation of Ifng in the context of Regnase-1 deletion. Despite the notable increase in Ifng mRNA expression in Reg-1ΔNK-NK cells, Ifng was not a direct substrate of Regnase-1. However, the production of the IFN-γ was further enhanced upon stimulation with IL-12/18. We proposed that modifications may have occurred in the transcriptional regulation of Ifng in Reg-1ΔNK-NK cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE237637 | GEO | 2024/05/30

REPOSITORIES: GEO

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