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Utilization of Tagged Transgenic Mouse Lines to Study the Molecular Roles of SMAD1/5 in Mediating Signaling Crosstalk During Early Pregnancy II

ABSTRACT: In this study, we generated two novel transgenic mouse lines with HA- or PA- affinity tags in the SMAD1 and SMAD5 loci (Smad1HA/HA and Smad5PA/PA) to define how these proteins integrate BMP signaling in the uterus during early pregnancy. Using CUT & RUN, we provided genomic evidence demonstrating the unique and shared roles of SMAD1 and SMAD5 during the window of implantation.

ORGANISM(S): Mus musculus

PROVIDER: GSE237975 | GEO | 2024/02/29

REPOSITORIES: GEO

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Comparsion of Smad1 and Smad5 Dependent Transcript Profiles in Zebrafish

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