RNA-seq of BV2 cultured microglia following high glucose and CD200Fc treatments
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ABSTRACT: We observe dyseregulated CD200-CD200R signaling in early diabetes that correlates with microglia-mediated neuroretinopathy and found that CD200 fusion protein (CD200Fc), an agonist of CD200R, attenuated high glucose-induced inflammation in cultured microglia. Therefore, we performed RNA-Sequencing on cultured BV2 microglia following exposure to normal or high glucose media (NG, HG) with or without CD200Fc supplementation (50ng/mL) to investigate broader biologic implications.
ORGANISM(S): Mus musculus
PROVIDER: GSE238008 | GEO | 2023/10/30
REPOSITORIES: GEO
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