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Identification of expression patterns of FoxP1 in the kidneys using RiboTag mice and RNA sequencing

ABSTRACT: Intercalated cells within renal tubules play a vital role in maintaining body acid-base balance through H+ and HCO3- secretion. Disruptions in intercalated cell differentiation or channel activity due to gene mutations can lead to distal renal tubular acidosis (dRTA), yet the precise mechanisms governing this process remain poorly understood. This study identified Foxp1 and its downstream factors as novel essential factors for intercalated cell differentiation, thus shed light on potential underlying mechanisms in some unresolved cases of dRTA.

ORGANISM(S): Mus musculus

PROVIDER: GSE238266 | GEO | 2024/02/27

REPOSITORIES: GEO

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