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Maternal adipose tissue DNA methylation and gene expression associated with excessive gestational weight gain

ABSTRACT: Omental adipose tissue was obtained from 24 women aged 25-40 years with a healthy singleton pregnancy and a pre-pregnancy BMI of 18.5-26 kg/m2. Genomic DNA was extracted for promoter DNA methylation analysis of candidate genes LEP, TNF, NPY, POMC and SOCS3 using bisulfite amplicon sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE239408 | GEO | 2024/07/26

REPOSITORIES: GEO

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Comparative transcriptomic analyses of developing melanocortin neurons reveal new regulators for the anorexigenic neuron identity

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2020-03-12 | GSE146816 | GEO

Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenaline

Project description:The arcuate nucleus of the hypothalamus (ARH) is one key structure controlling energy homeostasis. While it has been shown that the biogenic amines dopamine and serotonin modulate food intake controlling NPY/AgRP and/or POMC neurons in the ARH, the neural substrates that mediate the effect of noradrenaline (NA) on energy homeostasis remain elusive. By electrophysiological recordings and cell type-specific transcriptomics we show that the main neuronal populations in the ARH, NPY/AgRP and POMC neurons express a combination of excitatory and inhibitory adrenergic receptors (ARs). Surprisingly, NA had a clear differential effect on these neurons. Activation of NPY/AgRP neurons is mediated by _1A - and _- ARs, while POMC neurons are inhibited via _2A ARs. Collectively, our data indicate an orexigenic influence of NA on the ARH circuitry that controls energy balance

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Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature

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Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenaline

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| PRJNA415839 | ENA

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Salivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome

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Project description:Singleton Filtering

| PRJNA392425 | ENA

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