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AP-3-84 effects on gene expression in thioglycollate-induced, ID8 ascites or bone-marrow derived macrophages

ABSTRACT: Here we studied the effects of AP-3-84 treatment on gene expression in different types of macrophages: thioglycollate-induced macrophages, ascites macrophages from ID8 ovarian cancer-bearing mice, bone marrow-derived macrophages. We also studied whether AP-3-84 effects are mediated by p53 using bone marrow-derived macrophages from p53 KO mice. We found the dramatic changes in gene expression upon AP-3-84 treatment in all types of macrophages with the induction of major stress response programs and apoptosis signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE239479 | GEO | 2024/07/26

REPOSITORIES: GEO

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AP-3-84 effects on gene expression in thioglycollate-induced, ID8 ascites or bone-marrow derived macrophages

Project description:AP-3-84 effects on gene expression in thioglycollate-induced, ID8 ascites or bone-marrow derived macrophages

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