Vagal Sensory Neuron-Derived FGF3 Regulates Insulin Secretion and Energy Balance

ABSTRACT: The vagus nerve has long been associated with the regulation of energy balance. However, the identity of the molecules mediating these effects remain largely unknown. Here, we used RNA sequencing to interrogate the molecular repertoire of the mouse vagal afferents. We found that Fgf3 mRNA is upregulated in the jugular-nodose ganglia under acute insulin resistance. Together, we provide evidence for efferent-like roles of the vagal afferents and identify Fgf3 as a novel vagal sensory-derived metabolic hormone that regulates insulin secretion and energy expenditure.

ORGANISM(S): Mus musculus

PROVIDER: GSE239596 | GEO | 2024/08/04

REPOSITORIES: GEO