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Effect of TP53 missense mutation R172H on the single cell gene expression of pre-neoplastic mouse mammary gland

ABSTRACT: Mutations in the TP53 gene are the most common genetic alterations in breast cancer. To investigate at a single cell level what is the gene expression network that is regulated by mutant p53 at a non-tumoral stage, we employed a pre-neoplastic mouse model harboring the germline hotspot missense mutation R172H. We thus performed scRNAseq of cells derived from the normal mammary glands of mice harboring wt or mutant p53.

ORGANISM(S): Mus musculus

PROVIDER: GSE239706 | GEO | 2023/10/06

REPOSITORIES: GEO

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