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Aedes aegypti NeSt1 interacts with human CD47 to enhance Zika virus infectivity

ABSTRACT: Aedes aegypti is a vector of many infectious agents, including flaviviruses like Zika virus. We demonstrate that Nest1, a 34kDa mosquito salivary protein, facilitates Zika virus dissemination in human skin explants. Our aim was to analyze the effect of Nest1 at a transcriptomic level (RNAseq) in human skin explants, in the presence and absence of virus (ZIKV), at different timepoints (day 1, 2,3 ,and 4)

ORGANISM(S): Homo sapiens

PROVIDER: GSE239840 | GEO | 2024/12/05

REPOSITORIES: GEO

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Aedes aegypti NeSt1 interacts with human CD47 to enhance Zika virus infectivity

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